abstract：:Pulmonary hypertension (PH) in newborns and adults is a disease that can lead to right heart failure and result in a shorter lifespan. PH was induced by maintaining pregnant rats in a hypoxic chamber for 4 h twice a day, from days 7‑21 of pregnancy. Hypoxia was confirmed by a decrease in the partial pressure of oxygen...

journal_title：Molecular medicine reports

authors： Ding H,Luo Y,Hu K,Huang H,Liu P,Xiong M,Zhu L,Yi J,Xu Y

更新日期：2020-11-01 00:00:00

abstract：:Ras‑GTPase‑activating protein SH3 domain‑binding protein 1 (G3BP1) has been reported to be of importance in the occurrence and development of colon cancer. However, the underlying mechanisms remain largely unknown. Therefore, the aim of the present study was to investigate the role of Wnt/β‑catenin signaling in G3BP1‑...

journal_title：Molecular medicine reports

authors： Li Y,Wang J,Zhong S,Li J,Du W

更新日期：2020-11-01 00:00:00

abstract：:The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF‑1α during the healing process. HIF‑1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the expression levels of molecules such as stromal cell‑derived factor‑...

journal_title：Molecular medicine reports

authors： Xue Y,Li Z,Wang Y,Zhu X,Hu R,Xu W

更新日期：2020-10-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized by fibrosis of the skin and visceral organs, and peripheral circulatory disturbance. α2‑antiplasmin (α2AP) is the major circulating inhibitor of plasmin and is a key regulator of fibrinolysis. It has been demonstrated that the e...

journal_title：Molecular medicine reports

authors： Niwa H,Kanno Y,Shu E,Seishima M

更新日期：2020-10-01 00:00:00

abstract：:Pancreatic cancer (PC) is the fourth most common cause of cancer‑related mortality worldwide and is characterized by high invasiveness and early metastasis. To identify novel diagnostic markers, the present study aimed to understand the mechanism underlying PC progression. The present study demonstrated that exosomes ...

journal_title：Molecular medicine reports

authors： Wei Q,Wei L,Zhang J,Li Z,Feng H,Ren L

更新日期：2020-10-01 00:00:00

abstract：:The association of the peripheral lymphocyte‑to‑monocyte ratio (LMR) with α‑fetoprotein (AFP) status in patients with AFP‑positive and AFP‑negative hepatocellular carcinoma (HCC) has not been investigated in detail. The aim of the present study was to examine the association between the LMR and AFP status in these pat...

journal_title：Molecular medicine reports

authors： Wang H,Xiang Y,Li X,Liu S,Liu L

更新日期：2020-10-01 00:00:00

abstract：:Astronauts are inevitably exposed to two major risks during space flight, microgravity and radiation. Exposure to microgravity has been discovered to lead to rapid and vigorous bone loss due to elevated osteoclastic activity. In addition, long‑term exposure to low‑dose‑rate space radiation was identified to promote DN...

journal_title：Molecular medicine reports

authors： Furusawa Y,Yamamoto T,Hattori A,Suzuki N,Hirayama J,Sekiguchi T,Tabuchi Y

更新日期：2020-10-01 00:00:00

abstract：:The occurrence and development of hyperglycemia‑induced inflammation is associated with increased expression of receptor for advanced glycation end products (RAGE) and inflammatory factors, including IL‑1β, TNF‑α and IL‑6. Previous studies have reported that the nucleotide‑binding oligomerization domain‑like receptor ...

journal_title：Molecular medicine reports

authors： Jiang M,Wang X,Wang P,Peng W,Zhang B,Guo L

更新日期：2020-10-01 00:00:00

abstract：:Icariside II (ICAII) is a bioflavonoid compound which has demonstrated anti‑oxidative, anti‑inflammatory and anti‑apoptotic biological activities. However, to the best of our knowledge, whether ICAII can alleviate myocardial ischemia and reperfusion injury (MIRI) remains unknown. The aim of the present study was to de...

journal_title：Molecular medicine reports

authors： Guan BF,Dai XF,Huang QB,Zhao D,Shi JL,Chen C,Zhu Y,Ai F

更新日期：2020-10-01 00:00:00

abstract：:Diabetes mellitus poses a major threat towards global heath due to a lack of effective treatment. Fluoxetine hydrochloride, a selective 5‑hydroxytryptamine reuptake inhibitor, is the most commonly used antidepressant in clinical therapy; however, the potential molecular mechanisms of fluoxetine in diabetes remain unkn...

journal_title：Molecular medicine reports

authors： Yang H,Cao Q,Xiong X,Zhao P,Shen D,Zhang Y,Zhang N

更新日期：2020-10-01 00:00:00

abstract：:Infantile hemangioma (IH) is one of the most common vascular tumors that occurs during childhood, but its pathogenesis is currently not completely understood. Even though lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) plays vital roles in tumorigenesis of malignant tumors, its roles in IH remain unclear. The...

journal_title：Molecular medicine reports

authors： Yu L,Shu H,Xing L,Lv MX,Li L,Xie YC,Zhang Z,Zhang L,Xie YY

更新日期：2020-10-01 00:00:00

abstract：:Lower back pain (LBP) is one of the predominant factors contributing to dyskinesia and remains a serious social and economic burden worldwide. Intervertebral disc degeneration (IDD) is the leading cause of LBP; the existing IDD treatments cannot completely prevent IDD. Circular RNAs (circRNAs) are non‑coding RNAs resu...

journal_title：Molecular medicine reports

authors： Li Y,Zhou S,Peng P,Wang X,Du L,Huo Z,Xu B

更新日期：2020-10-01 00:00:00

abstract：:Hydroxyapatite scaffolds (HASs) are widely studied as suitable materials for bone replacement scaffolds due to their chemical similarities to organic materials. In our previous study, a novel HAS with a 25‑30‑µm groove structure (HAS‑G) exhibited enhanced osteogenesis of bone mesenchymal stromal cells (BMSCs) compared...

journal_title：Molecular medicine reports

authors： Li C,Yang L,Ren X,Lin M,Shen D,Li Y,Zhang X,Liu C,Mu Y

更新日期：2020-10-01 00:00:00

abstract：:Following the publication of the above article, an interested reader drew to the authors' attention that a pair of the data panels shown in Fig. 4 contained overlapping data. After having consulted their original data, the authors realized that a total of three panels featured in Figs. 4 and 6 had been erroneously sel...

journal_title：Molecular medicine reports

authors： Xu F,Wu H,Zhang K,Lv P,Zheng L,Zhao J

更新日期：2020-09-01 00:00:00

abstract：:Reamed intramedullary nailing (RIN) is a surgical method of choice for treatment of diaphyseal fractures. This procedure affects the biological environment of bone tissue locally and systemically. This study investigated the influence of RIN on mesenchymal stem cells (MSCs) in patients with long bone fractures. The ax...

journal_title：Molecular medicine reports

authors： Sperelakis I,Tsitoura E,Koutoulaki C,Mastrodimou S,Tosounidis TH,Dimitriou H,Spandidos DA,Antoniou KM,Kontakis G

更新日期：2020-09-01 00:00:00

abstract：:Cadmium (Cd) is a heavy metal that can accumulate and cause damage to a variety of tissues and organs. The kidney is the primary target organ for Cd accumulation and toxic damage. Autophagy, which is a critical intracellular process, serves an important role in maintaining the homeostasis of the intracellular environm...

journal_title：Molecular medicine reports

authors： Liu G,Zhang K,Dong W,Tan Y,Long M,Zou H,Liu Z

更新日期：2020-09-01 00:00:00

abstract：:Thyroid cancer (TC) is a frequently occurring malignant tumor with a rising steadily incidence. microRNA (miRNA/miR)‑193a‑3p is an miRNA that is associated with tumors, playing a crucial role in the genesis and progression of various cancers. However, the expression levels of miR‑193a‑3p and its molecular mechanisms i...

journal_title：Molecular medicine reports

authors： Li XJ,Wen R,Wen DY,Lin P,Pan DH,Zhang LJ,He Y,Shi L,Qin YY,Lai YH,Lai JN,Yang JL,Lai QQ,Wang J,Ma J,Yang H,Pang YY

更新日期：2020-09-01 00:00:00

abstract：:Ovarian cancer is the most frequent cause of death among gynecological cancers. In the present study, the anti‑cancer effect of liriopesides B, a steroidal saponin from Liriope spicata var. prolifera, against A2780 cells was investigated. Transwell chambers were adopted to assess its effect on cell invasion and chemot...

journal_title：Molecular medicine reports

authors： Yu H,Wang H,Yin Y,Wang Z

更新日期：2020-09-01 00:00:00

abstract：:Growth arrest‑specific 5 (GAS5) is a known tumor suppressor which negatively regulates cell survival and malignancy in several cancer cell types. The present study aimed to establish the correlation between GAS5 and unc‑51 like autophagy activating kinase (ULK)1/2, two key regulators of autophagy initiation in breast ...

journal_title：Molecular medicine reports

authors： Li G,Qian L,Tang X,Chen Y,Zhao Z,Zhang C

更新日期：2020-09-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignant bone tumor among children and young people and is associated with poor prognosis. Punicalagin is an antioxidant ellagitannin found in pomegranate juice with known antiproliferation and anti‑angiogenesis properties. However, the antitumor effect of punicalagin on osteos...

journal_title：Molecular medicine reports

authors： Huang T,Zhang X,Wang H

更新日期：2020-09-01 00:00:00

abstract：:The aim of the present study was to establish an integrated network of DNA methylation and RNA expression in an ovalbumin (OVA)‑induced asthma model, and to investigate the epigenetically‑regulated genes involved in asthma development. Genome‑wide CpG‑DNA methylation profiling was conducted through the use of a methyl...

journal_title：Molecular medicine reports

authors： Kim JS,Shin IS,Shin NR,Nam JY,Kim C

更新日期：2020-09-01 00:00:00

abstract：:The present study aimed to determine the potential molecular mechanisms underlying p21 (RAC1)‑activated kinase 7 (PAK7) expression in glioblastoma (GBM) and evaluate candidate prognosis biomarkers for GBM. Gene expression data from patients with GBM, including 144 tumor samples and 5 normal brain samples, were downloa...

journal_title：Molecular medicine reports

authors： Wang X,Liu S,Shao Z,Zhang P

更新日期：2020-08-01 00:00:00

abstract：:Glaucoma is a group of progressive optic neuropathies that have in common characteristic optic nerve head changes, loss of retinal ganglion cells and visual field defects. Among the large family of glaucomas, primary open‑angle glaucoma (POAG) is the most common type, a complex and heterogeneous disorder with environm...

journal_title：Molecular medicine reports

authors： Trivli A,Zervou MI,Goulielmos GN,Spandidos DA,Detorakis ET

更新日期：2020-08-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a type of diabetes mellitus (DM) that occurs during pregnancy. The present study aimed to investigate the roles of microRNA (miR)‑195‑5p and enhancer of zeste homolog 2 (EZH2) in GDM, and their potential association. Human umbilical vein endothelial cells (HUVECs) were collected ...

journal_title：Molecular medicine reports

authors： Liao X,Zhou Z,Zhang X

更新日期：2020-08-01 00:00:00

abstract：:Quantification of testosterone serves an important role in the differential diagnosis of androgen‑related endocrine diseases. Mass spectrometry exhibits higher accuracy and lower variability than immunoassays, especially at low testosterone concentrations. The present study developed and validated an isotope dilution ...

journal_title：Molecular medicine reports

authors： Sun G,Xue J,Li L,Li X,Cui Y,Qiao B,Wei D,Li H

更新日期：2020-08-01 00:00:00

abstract：:The increasing burden of diabetes in low and middle‑income countries is attributable to both genetic and epigenetic factors. Environmental‑ and lifestyle‑associated changes are also considered to be important contributors to this disease. The resultant co‑morbidities arising from micro‑and macrovascular changes in dia...

journal_title：Molecular medicine reports

authors： Yu Z,Zhang W,Zhang X,Xu D,Wang N

更新日期：2020-08-01 00:00:00

abstract：:Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the main causes of death and nervous system damage in neonates. The aim of the present study was to investigate the effect of the Toll‑like receptor 4 (TLR4) antagonist TAK‑242 on HIE. The Rice‑Vannucci method was used for ligation of the left common carotid art...

journal_title：Molecular medicine reports

authors： Jiang L,Xu Z,Li H,Wu M,Wang F,Liu S,Tao J,Feng X

更新日期：2020-08-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1), a traditional Chinese herb extracted from Bolbostemma paniculatum (Maxim.), induces apoptosis in a number of human cancer cell lines. TBMS1 has been reported to induce apoptosis in human glioma cells, however the mechanism remains to be elucidated. The present study explored TBMS1‑induced PI3K/A...

journal_title：Molecular medicine reports

authors： Cao LJ,Xie HT,Chu ZX,Ma Y,Wang MM,Shi Z

更新日期：2020-08-01 00:00:00

abstract：:Prenatal clinical detection of thalassemia involves gap‑PCR and reverse dot blot (RDB) analysis of fetal DNA acquired through invasive methods. The present study aimed to develop a non‑invasive prenatal diagnostic method for thalassemia based on next‑generation sequencing (NGS). A total of eight families with proband ...

journal_title：Molecular medicine reports

authors： Yang X,Ye Y,Fan D,Lin S,Li M,Hou H,Zhang J,Yang X

更新日期：2020-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and malignant brain tumor of the adult central nervous system and is associated with poor prognosis. The present study aimed to identify the hub genes in GBM in order to improve the current understanding of the underlying mechanism of GBM. The RNA‑seq data were download...

journal_title：Molecular medicine reports

authors： Chen X,Pan Y,Yan M,Bao G,Sun X

更新日期：2020-08-01 00:00:00

abstract：:The present study aimed to explore the effect of Saikosaponin D (SSD) and its underlying mechanism on apoptosis and autophagy in human breast cancer MDA‑MB‑231 cells. MTT assay, flow cytometry, western blotting and confocal fluorescence microscopy detection were employed. SSD, a kind of triterpenoid saponins extracted...

journal_title：Molecular medicine reports

authors： Fu R,Zhang L,Li Y,Li B,Ming Y,Li Z,Xing H,Chen J

更新日期：2020-08-01 00:00:00

abstract：:Advanced glycosylation end-product specific receptor (AGER) is a multi-ligand cell surface receptor abnormally expressed in lung cancer, and is a member of the immunoglobulin superfamily. Therefore, this study aimed to explore the effect of AGER on the biological behavior of non‑small cell lung cancer (NSCLC) H1299 ce...

journal_title：Molecular medicine reports

authors： Wang Q,Zhu W,Xiao G,Ding M,Chang J,Liao H

更新日期：2020-08-01 00:00:00

abstract：:Neutrophilic asthma (NA) is characterized by neutrophil‑mediated inflammation and the presence of Th17 cells. However, the mechanisms underlying Th17 cell responses in NA remain unknown. The aim of the present study was to examine the effects of interleukin (IL)‑7 on Th17 cell responses in NA. A NA mouse model was sen...

journal_title：Molecular medicine reports

authors： Zhang X,Zhang M,Jiang M,Nong G

更新日期：2020-08-01 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumour and the second leading cause of cancer‑related death in children and adolescents. Microwave ablation has an excellent therapeutic effect on bone tumours by instantaneously increasing the temperature in the tumour; however, there is a risk of damaging the surroundin...

journal_title：Molecular medicine reports

authors： Chen L,Wang M,Lin Z,Yao M,Wang W,Cheng S,Li B,Zhang Y,Yin Q

更新日期：2020-08-01 00:00:00

abstract：:Mechanical allodynia, which develops in patients of diabetes mellitus as a neuropathic manifestation, remains without an effective treatment. The aim of the present study was to investigate the effects and potential mechanisms underlying resveratrol (RES) in a rat model of streptozocin (STZ)‑induced diabetic mechanica...

journal_title：Molecular medicine reports

authors： Cui Y,Li Y,Ning J,Mi Y,Wang X,Qiu Z,Li L,Gou X

更新日期：2020-08-01 00:00:00

abstract：:The use of human bone marrow mesenchymal stem cells (hBMSCs) as a tissue engineering application for individuals affected by osteoporosis and other types of bone loss diseases has been well studied in recent years. The osteogenic differentiation of hBMSCs can be regulated by a number of cues. MicroRNAs (miRNAs/miRs) s...

journal_title：Molecular medicine reports

authors： Zhang Y,Zhou L,Zhang Z,Ren F,Chen L,Lan Z

更新日期：2020-07-01 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA), especially in mitochondrial 12S rRNA and transfer RNA(tRNA)Ser(UCN) genes, are important causes of non‑syndromic hearing loss. However, the molecular mechanism underlying mt‑tRNA mutations in clinical hearing impairment are not fully understood. The present study assessed the mo...

journal_title：Molecular medicine reports

authors： Peng W,Zhong Y,Zhao X,Yuan J

更新日期：2020-07-01 00:00:00

abstract：:Acute intermittent porphyria (AIP) is a rare inherited disorder, which is caused by the partial deficiency of hydroxymethylbilane synthase (HMBS), an enzyme of the heme biosynthetic pathway. Abdominal pain, neuropsychiatric disturbance and neuropathy are the typical manifestations of the disease. Complications such as...

journal_title：Molecular medicine reports

authors： Yang Y,Chen X,Wu H,Peng H,Sun W,He B,Yuan Z

更新日期：2020-07-01 00:00:00

abstract：:Previous studies have shown that caspase-1 plays an important role in the acute inflammatory response of spinal cord injury (SCI). VX‑765, a novel and irreversible caspase‑1 inhibitor, has been reported to effectively intervene in inflammation. However, the effect of VX‑765 on genome‑wide transcription in acutely inju...

journal_title：Molecular medicine reports

authors： Chen J,Chen YQ,Wang SN,Duan FX,Shi YJ,Ding SQ,Hu JG,Lü HZ

更新日期：2020-07-01 00:00:00

abstract：:The newly identified C1q/tumor necrosis factor (TNF)-related protein-6 (CTRP6) is a highly conserved paralog of adiponectin with modulatory effects on metabolism and inflammation. However, the role of CTRP6 in cerebral ischemia/reperfusion (I/R) injury remains unknown. The aim of the present study was to explore the p...

journal_title：Molecular medicine reports

authors： Li Y,Sun J,Gu L,Gao X

更新日期：2020-07-01 00:00:00